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{{Seed}}
[[Image:2jym.png|left|200px]]


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==Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element==
The line below this paragraph, containing "STRUCTURE_2jym", creates the "Structure Box" on the page.
<StructureSection load='2jym' size='340' side='right'caption='[[2jym]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jym]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jym OCA], [https://pdbe.org/2jym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jym RCSB], [https://www.ebi.ac.uk/pdbsum/2jym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jym ProSAT]</span></td></tr>
{{STRUCTURE_2jym|  PDB=2jym  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Chronic hepatitis B virus (HBV) infections may lead to severe diseases like liver cirrhosis or hepatocellular carcinoma (HCC). The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3'-region of all viral transcripts. The HPRE consists of three sub-elements alpha (nucleotides 1151-1346), beta1 (nucleotides 1347-1457) and beta2 (nucleotides 1458-1582), which confer together full export competence. Here, we present the NMR solution structure (pdb 2JYM) of the stem-loop alpha (SLalpha, nucleotides 1292-1321) located in the sub-element alpha. The SLalpha contains a CAGGC pentaloop highly conserved in hepatoviruses, which essentially adopts a CUNG-like tetraloop conformation. Furthermore, the SLalpha harbours a single bulged G residue flanked by A-helical regions. The structure is highly suggestive of serving two functions in the context of export of unspliced viral RNA: binding sterile alpha motif (SAM-) domain containing proteins and/or preventing the utilization of a 3'-splice site contained within SLalpha.


===Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element===
Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element.,Schwalbe M, Ohlenschlager O, Marchanka A, Ramachandran R, Hafner S, Heise T, Gorlach M Nucleic Acids Res. 2008 Mar;36(5):1681-9. Epub 2008 Feb 7. PMID:18263618<ref>PMID:18263618</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18263618}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2jym" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18263618 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_18263618}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2JYM is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA].
[[Category: Gorlach M]]
 
[[Category: Ohlenschlager O]]
==Reference==
[[Category: Schwalbe M]]
Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element., Schwalbe M, Ohlenschlager O, Marchanka A, Ramachandran R, Hafner S, Heise T, Gorlach M, Nucleic Acids Res. 2008 Mar;36(5):1681-9. Epub 2008 Feb 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18263618 18263618]
[[Category: Single protein]]
[[Category: Gorlach, M.]]
[[Category: Ohlenschlager, O.]]
[[Category: Schwalbe, M.]]
[[Category: Hepatitis b virus]]
[[Category: Nmr solution structure]]
[[Category: Post-transcriptional regulatory element]]
[[Category: Rna]]
[[Category: Stem-loop alpha]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:03:41 2008''

Latest revision as of 12:49, 20 December 2023

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element

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