1s06: Difference between revisions

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{{Seed}}
[[Image:1s06.png|left|200px]]


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==Crystal Structure of the R253K Mutant of 7,8-Diaminopelargonic Acid Synthase==
The line below this paragraph, containing "STRUCTURE_1s06", creates the "Structure Box" on the page.
<StructureSection load='1s06' size='340' side='right'caption='[[1s06]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1s06]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S06 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
{{STRUCTURE_1s06| PDB=1s06 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s06 OCA], [https://pdbe.org/1s06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s06 RCSB], [https://www.ebi.ac.uk/pdbsum/1s06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s06 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIOA_ECOLI BIOA_ECOLI] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.<ref>PMID:1092681</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s0/1s06_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s06 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the R253K Mutant of 7,8-Diaminopelargonic Acid Synthase===
==See Also==
 
*[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_14756557}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 14756557 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_14756557}}
 
==About this Structure==
1S06 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S06 OCA].
 
==Reference==
Conserved and nonconserved residues in the substrate binding site of 7,8-diaminopelargonic acid synthase from Escherichia coli are essential for catalysis., Sandmark J, Eliot AC, Famm K, Schneider G, Kirsch JF, Biochemistry. 2004 Feb 10;43(5):1213-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14756557 14756557]
[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Eliot, A C.]]
[[Category: Eliot AC]]
[[Category: Famm, K.]]
[[Category: Famm K]]
[[Category: Kirsch, J F.]]
[[Category: Kirsch JF]]
[[Category: Sandmark, J.]]
[[Category: Sandmark J]]
[[Category: Schneider, G.]]
[[Category: Schneider G]]
[[Category: Aminotransferase]]
[[Category: Fold type i]]
[[Category: Homodimer]]
[[Category: Subclass ii]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:19:57 2008''

Latest revision as of 06:13, 3 April 2024

Crystal Structure of the R253K Mutant of 7,8-Diaminopelargonic Acid Synthase

1s06, resolution 2.20Å

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