1sew: Difference between revisions
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{{Theoretical_model}} | |||
==MEMBRANE CHANNEL STRUCTURE OF HELICOBACTER PYLORI VACUOLATING TOXIN A== | |||
<StructureSection load='1sew' size='340' side='right'caption='[[1sew]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SEW FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sew FirstGlance], [https://www.ebi.ac.uk/pdbsum/1sew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sew ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Helicobacter pylori is a human pathogen responsible for severe gastric diseases such as peptic ulcers, gastric adenocarcinoma, and gastric lymphoma. Vacuolating toxin (VacA) is crucial in facilitating the colonization of the gastric lining by inducing cell apoptosis and immune suppression. VacA inserts into membranes and forms a hexameric, anion-selective pore. Here we present a structural model of the VacA pore that strongly resembles the structure of an unrelated anion-selective channel, MscS. In our model, Gly residues in GXXXG motifs pack against small Ala or Val side chains to generate the pore. Our model suggests that the same design of two anion-selective channels was achieved by two different evolutionary paths and provides insight into the mechanism of VacA function. | |||
Membrane channel structure of Helicobacter pylori vacuolating toxin: role of multiple GXXXG motifs in cylindrical channels.,Kim S, Chamberlain AK, Bowie JU Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5988-91. Epub 2004 Apr 5. PMID:15067113<ref>PMID:15067113</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1sew" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Bowie, J U]] | |||
[[Category: Chamberlain, A K]] | |||
[[Category: Kim, S]] | |||
Latest revision as of 07:30, 22 September 2021
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MEMBRANE CHANNEL STRUCTURE OF HELICOBACTER PYLORI VACUOLATING TOXIN A
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