1tbi: Difference between revisions
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{{Theoretical_model}} | |||
==TERTIARY MODEL OF EXTRACELLULAR DOMAIN OF TYPE I RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA, THEORETICAL MODEL== | |||
<StructureSection load='1tbi' size='340' side='right'caption='[[1tbi]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBI FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbi FirstGlance], [https://www.ebi.ac.uk/pdbsum/1tbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbi ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We have observed that the extracellular domain of T beta RI and protectin (CD59), an inhibitor of the membrane attack complex of complement, share structural features, a distinct spacing of ten cysteines and a C-terminal 'Cys-box'. Based on these common features and the recently determined NMR-structure of protectin, a three-dimensional model for the extracellular domain of T beta RI was constructed. After energy minimization and molecular dynamics simulation, a structure with four extending fingers (pes quattvordigitorum) and two clusters of charged residues was obtained. This model provides a view to the understanding of interactions between T beta RI, T beta RII and TGF beta during ligand recognition and signal transduction. | |||
Extracellular domain of type I receptor for transforming growth factor-beta: molecular modelling using protectin (CD59) as a template.,Jokiranta TS, Tissari J, Teleman O, Meri S FEBS Lett. 1995 Nov 27;376(1-2):31-6. PMID:8521960<ref>PMID:8521960</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1tbi" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Jokiranta, T S]] | |||
[[Category: Meri, S]] | |||
[[Category: Teleman, O]] | |||
[[Category: Tissari, J]] | |||
Latest revision as of 09:25, 29 September 2021
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TERTIARY MODEL OF EXTRACELLULAR DOMAIN OF TYPE I RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA, THEORETICAL MODEL
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