3dzw: Difference between revisions
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New page: '''Unreleased structure''' The entry 3dzw is ON HOLD Authors: Rizkallah, P.J., zbey, S., Sauerborn, M.K. Description: Structure of Narcissus pseudonarcissus lectin complex with Mannobi... |
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==Structure of Narcissus pseudonarcissus lectin complex with Mannobiose at 1.7 A resolution, form II== | |||
<StructureSection load='3dzw' size='340' side='right'caption='[[3dzw]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3dzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Narcissus_pseudonarcissus Narcissus pseudonarcissus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzw OCA], [https://pdbe.org/3dzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dzw RCSB], [https://www.ebi.ac.uk/pdbsum/3dzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LEC_NARPS LEC_NARPS] D-mannose-binding lectin which binds alpha-D-linked mannose (PubMed:10388566, PubMed:14505313, PubMed:1645507, PubMed:1874921, PubMed:2350177). Displays a high affinity for alpha-(1-6)-mannose oligomers (PubMed:1645507, PubMed:2350177). Able to interact with both terminal and internal alpha-D-mannosyl residues (PubMed:2350177). Displays antiviral activity and therefore may contribute to defense against infections (PubMed:1645507, PubMed:7481093).<ref>PMID:10388566</ref> <ref>PMID:14505313</ref> <ref>PMID:1645507</ref> <ref>PMID:1874921</ref> <ref>PMID:2350177</ref> <ref>PMID:7481093</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/3dzw_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dzw ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Agglutinin 3D structures|Agglutinin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Narcissus pseudonarcissus]] | |||
[[Category: Ozbey S]] | |||
[[Category: Rizkallah PJ]] | |||
[[Category: Sauerborn MK]] | |||
