2jzx: Difference between revisions

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{{Seed}}
[[Image:2jzx.jpg|left|200px]]


<!--
==PCBP2 KH1-KH2 domains==
The line below this paragraph, containing "STRUCTURE_2jzx", creates the "Structure Box" on the page.
<StructureSection load='2jzx' size='340' side='right'caption='[[2jzx]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzx OCA], [https://pdbe.org/2jzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzx RCSB], [https://www.ebi.ac.uk/pdbsum/2jzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzx ProSAT]</span></td></tr>
{{STRUCTURE_2jzx|  PDB=2jzx  |  SCENE=  }}
</table>
 
== Function ==
===PCBP2 KH1-KH2 domains===
[https://www.uniprot.org/uniprot/PCBP2_HUMAN PCBP2_HUMAN] Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.<ref>PMID:19881509</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2JZX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZX OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jzx ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Du, Z.]]
[[Category: Du Z]]
[[Category: Fenn, S.]]
[[Category: Fenn S]]
[[Category: James, T.]]
[[Category: James T]]
[[Category: Tjhen, R.]]
[[Category: Tjhen R]]
[[Category: Cytoplasm]]
[[Category: Dna-binding]]
[[Category: Kh domain]]
[[Category: Nucleus]]
[[Category: Pcbp2]]
[[Category: Phosphoprotein]]
[[Category: Ribonucleoprotein]]
[[Category: Rna binding]]
[[Category: Rna binding protein]]
[[Category: Rna-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 14:19:12 2008''
Retrieved from "https://proteopedia.org/2jzx"