2vn2: Difference between revisions

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{{Seed}}
[[Image:2vn2.jpg|left|200px]]


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==Crystal structure of the N-terminal domain of DnaD protein from Geobacillus kaustophilus HTA426==
The line below this paragraph, containing "STRUCTURE_2vn2", creates the "Structure Box" on the page.
<StructureSection load='2vn2' size='340' side='right'caption='[[2vn2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2vn2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VN2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2vn2|  PDB=2vn2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vn2 OCA], [https://pdbe.org/2vn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vn2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vn2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5KXY1_GEOKA Q5KXY1_GEOKA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vn2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vn2 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The DnaD is one of the primosomal proteins that are required for initiation and re-initiation of chromosomal DNA replication in Gram-positive bacteria. The DnaD protein is composed of two major structural domains: an N-terminal oligomerization domain and a C-terminal ssDNA binding domain. Here, we report the crystal structure of the N-terminal domain (aa 1-128) of DnaD (DnaDn) of Geobacillus kaustophilus HTA426 at 2.3A resolution. The structure of DnaDn reveals an extended winged-helix fold, a typical double-stranded DNA binding motif as winged-helix proteins. DnaDn formed tetramers in the crystalline state, but the results of gel filtration chromatography further indicated that this domain of DnaD was a stable dimer in solution. The structural analysis of DnaDn may suggest the binding sites for DNA and DnaB, and an assembly mechanism for Gram-positive bacterial DNA replication primosome.


===CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF DNAD PROTEIN FROM GEOBACILLUS KAUSTOPHILUS HTA426===
Crystal structure of the N-terminal domain of Geobacillus kaustophilus HTA426 DnaD protein.,Huang CY, Chang YW, Chen WT Biochem Biophys Res Commun. 2008 Oct 17;375(2):220-4. Epub 2008 Aug 12. PMID:18703019<ref>PMID:18703019</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2VN2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_kaustophilus_hta426 Geobacillus kaustophilus hta426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VN2 OCA].
<div class="pdbe-citations 2vn2" style="background-color:#fffaf0;"></div>
[[Category: Geobacillus kaustophilus hta426]]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Chang, Y W.]]
__TOC__
[[Category: Chen, W T.]]
</StructureSection>
[[Category: Hsiao, C D.]]
[[Category: Geobacillus kaustophilus HTA426]]
[[Category: Huang, C Y.]]
[[Category: Large Structures]]
[[Category: Sun, Y J.]]
[[Category: Chang Y-W]]
[[Category: Dna replication]]
[[Category: Chen W-T]]
[[Category: Dnad]]
[[Category: Hsiao C-D]]
[[Category: Primosome]]
[[Category: Huang C-Y]]
[[Category: Replication]]
[[Category: Sun Y-J]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 14:24:10 2008''

Latest revision as of 10:01, 9 May 2024

Crystal structure of the N-terminal domain of DnaD protein from Geobacillus kaustophilus HTA426

2vn2, resolution 2.30Å

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