1r1n: Difference between revisions
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New page: left|200px<br /><applet load="1r1n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r1n, resolution 1.74Å" /> '''Tri-nuclear oxo-iron... |
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== | ==Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae== | ||
We report a set of three 1.8-1.9 A resolution X-ray crystal structures of | <StructureSection load='1r1n' size='340' side='right'caption='[[1r1n]], [[Resolution|resolution]] 1.74Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1r1n]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CN1:OXO-IRON+CLUSTER+2'>CN1</scene>, <scene name='pdbligand=CNB:OXO-IRON+CLUSTER+1'>CNB</scene>, <scene name='pdbligand=CNF:OXO-IRON+CLUSTER+3'>CNF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1n OCA], [https://pdbe.org/1r1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1n RCSB], [https://www.ebi.ac.uk/pdbsum/1r1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1n ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FBP_NEIGO FBP_NEIGO] This protein may be a central component in the iron-acquisition system. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1n_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r1n ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We report a set of three 1.8-1.9 A resolution X-ray crystal structures of Neisseria gonorrhoeae Fbp (ferric-ion binding protein): (i) open-cleft apo-Fbp containing bound phosphate, (ii) open-cleft mono-Fe Fbp capped by nitrilotriacetate, and (iii) open-cleft trinuclear oxo-iron Fbp, the first structure of an iron-cluster adduct of a transferrin. The nine independent molecules in the unit cells provide 'snapshots' of the versatile dynamic structural roles of the conserved dityrosyl iron-binding motif (Tyr195-Tyr196) which control the capture and, possibly, processing of iron. These findings have implications for understanding bacterial iron acquisition and dissimilation, and organic/mineral interfaces. | |||
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.,Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:13129433<ref>PMID:13129433</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
<div class="pdbe-citations 1r1n" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Ferric-binding protein|Ferric-binding protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Neisseria gonorrhoeae]] | [[Category: Neisseria gonorrhoeae]] | ||
[[Category: Alexeev D]] | |||
[[Category: Alexeev | [[Category: Campopiano DJ]] | ||
[[Category: Campopiano | [[Category: Hunter DJ]] | ||
[[Category: Hunter | [[Category: Sadler PJ]] | ||
[[Category: Sadler | [[Category: Zhu H]] | ||
[[Category: Zhu | |||
Latest revision as of 09:40, 25 December 2024
Tri-nuclear oxo-iron clusters in the ferric binding protein from N. gonorrhoeae
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