TATA-Binding Protein

spinqualitylabelsall models Human TATA-binding protein complex with DNA TATA box (PDB code 1tgh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. Called the TATA box to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also Transcription and RNA Processing Yeast TATA Binding Protein. Additional information See: Transcription for additional Proteopedia resources Relevance TBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia. Structural highlights interact with the phosphate groups phenylalanine amino acids asparagine amino acids two symmetrical halves. The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic. 3D Structures of TATA-binding protein TATA-binding protein 3D structures

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Ala Jelani, Alexander Berchansky, David Canner, Michal Harel, Eran Hodis