2k7d: Difference between revisions

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New page: '''Unreleased structure''' The entry 2k7d is ON HOLD until Paper Publication Authors: Ames, J. Description: NMR Structure of Ca2+-bound CaBP1 C-domain ''Page seeded by [http://oca.wei...
 
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'''Unreleased structure'''


The entry 2k7d is ON HOLD  until Paper Publication
==NMR Structure of Ca2+-bound CaBP1 C-domain==
 
<StructureSection load='2k7d' size='340' side='right'caption='[[2k7d]]' scene=''>
Authors: Ames, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2k7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7D FirstGlance]. <br>
Description: NMR Structure of Ca2+-bound CaBP1 C-domain
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 10:51:04 2008''
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7d OCA], [https://pdbe.org/2k7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7d RCSB], [https://www.ebi.ac.uk/pdbsum/2k7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CABP1_HUMAN CABP1_HUMAN] Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).<ref>PMID:11865310</ref> <ref>PMID:14570872</ref> <ref>PMID:15140941</ref> <ref>PMID:15980432</ref> <ref>PMID:15895247</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7d ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ames J]]
Retrieved from "https://proteopedia.org/2k7d"