2k7f: Difference between revisions

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New page: '''Unreleased structure''' The entry 2k7f is ON HOLD Authors: Kobayashi, M., Ab, E., Bonvin, A., Siegal, G. Description: HADDOCK calculated model of the complex between the BRCT region...
 
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'''Unreleased structure'''


The entry 2k7f is ON HOLD
==HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA==
 
<StructureSection load='2k7f' size='340' side='right'caption='[[2k7f]]' scene=''>
Authors: Kobayashi, M., Ab, E., Bonvin, A., Siegal, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2k7f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7F FirstGlance]. <br>
Description: HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7f OCA], [https://pdbe.org/2k7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7f RCSB], [https://www.ebi.ac.uk/pdbsum/2k7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7f ProSAT]</span></td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 10:51:08 2008''
</table>
== Function ==
[https://www.uniprot.org/uniprot/RFC1_HUMAN RFC1_HUMAN] The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.<ref>PMID:8999859</ref>  Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.<ref>PMID:8999859</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7f ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ab E]]
[[Category: Bonvin A]]
[[Category: Kobayashi M]]
[[Category: Siegal G]]
Retrieved from "https://proteopedia.org/2k7f"