2w0i: Difference between revisions
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New page: '''Unreleased structure''' The entry 2w0i is ON HOLD Authors: ELKINS, J.M., PIKE, A.C.W., SALAH, E., SAVITSKY, P., MURRAY, J.W., ROOS, A., von DELFT, F., EDWARDS, A., ARROWSMITH, C.H., ... |
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==Structure Of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain Of Human Twinfilin-2== | |||
<StructureSection load='2w0i' size='340' side='right'caption='[[2w0i]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2w0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W0I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0i OCA], [https://pdbe.org/2w0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w0i RCSB], [https://www.ebi.ac.uk/pdbsum/2w0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0i ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TWF2_HUMAN TWF2_HUMAN] Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0i_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0i ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Twinfilin|Twinfilin]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Edwards A]] | |||
[[Category: Elkins JM]] | |||
[[Category: Knapp S]] | |||
[[Category: Murray JW]] | |||
[[Category: Pike ACW]] | |||
[[Category: Roos A]] | |||
[[Category: Salah E]] | |||
[[Category: Savitsky P]] | |||
[[Category: Wikstrom M]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 15:39, 13 December 2023
Structure Of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain Of Human Twinfilin-2
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