3e7k: Difference between revisions
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New page: '''Unreleased structure''' The entry 3e7k is ON HOLD Authors: Fujiwara, Y., Minor, D.L. Description: Crystal Structure of an antiparallel coiled-coil tetramerization domain from TRPM7 ... |
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==Crystal Structure of an antiparallel coiled-coil tetramerization domain from TRPM7 channels== | |||
<StructureSection load='3e7k' size='340' side='right'caption='[[3e7k]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3e7k]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7k OCA], [https://pdbe.org/3e7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7k RCSB], [https://www.ebi.ac.uk/pdbsum/3e7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7k ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TRPM7_RAT TRPM7_RAT] Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1) (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7k_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7k ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Fujiwara Y]] | |||
[[Category: Minor DL]] | |||
Latest revision as of 09:45, 21 February 2024
Crystal Structure of an antiparallel coiled-coil tetramerization domain from TRPM7 channels
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