1r7i: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
New page: left|200px<br /><applet load="1r7i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r7i, resolution 2.21Å" /> '''HMG-CoA Reductase fr...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1r7i.gif|left|200px]]<br /><applet load="1r7i" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1r7i, resolution 2.21&Aring;" />
'''HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.'''<br />


==About this Structure==
==HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.==
1R7I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase Hydroxymethylglutaryl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.88 1.1.1.88] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R7I OCA].  
<StructureSection load='1r7i' size='340' side='right'caption='[[1r7i]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
[[Category: Hydroxymethylglutaryl-CoA reductase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1r7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7I FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7i OCA], [https://pdbe.org/1r7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7i RCSB], [https://www.ebi.ac.uk/pdbsum/1r7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r7i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r7i ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas mevalonii]]
[[Category: Pseudomonas mevalonii]]
[[Category: Single protein]]
[[Category: Burgner JW]]
[[Category: Burgner, J.W.]]
[[Category: Lawrence CM]]
[[Category: Lawrence, C.M.]]
[[Category: Rodwell VW]]
[[Category: Rodwell, V.W.]]
[[Category: Stauffacher CV]]
[[Category: Stauffacher, C.V.]]
[[Category: Steussy CN]]
[[Category: Steussy, C.N.]]
[[Category: Tabernero L]]
[[Category: Tabernero, L.]]
[[Category: Watson JM]]
[[Category: Watson, J.M.]]
[[Category: GOL]]
[[Category: SO4]]
[[Category: 4-electron oxido-reductase]]
[[Category: oxidoreductase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:19:56 2007''
Retrieved from "https://proteopedia.org/1r7i"