3dls: Difference between revisions

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{{Seed}}
[[Image:3dls.jpg|left|200px]]


<!--
==Crystal structure of human PAS kinase bound to ADP==
The line below this paragraph, containing "STRUCTURE_3dls", creates the "Structure Box" on the page.
<StructureSection load='3dls' size='340' side='right'caption='[[3dls]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dls]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DLS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3dls|  PDB=3dls  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dls OCA], [https://pdbe.org/3dls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dls RCSB], [https://www.ebi.ac.uk/pdbsum/3dls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dls ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3dls TOPSAN]</span></td></tr>
 
</table>
===SGX CLONE 9501a6KWg1h1===
== Function ==
 
[https://www.uniprot.org/uniprot/PASK_HUMAN PASK_HUMAN] Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.<ref>PMID:16275910</ref> <ref>PMID:17052199</ref> <ref>PMID:17595531</ref> <ref>PMID:21181396</ref> <ref>PMID:21418524</ref> <ref>PMID:20943661</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3DLS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLS OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/3dls_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dls ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Antonysamy S]]
[[Category: Antonysamy, S.]]
[[Category: Bonanno JB]]
[[Category: Bonanno, J B.]]
[[Category: Burley SK]]
[[Category: Burley, S K.]]
[[Category: Gheyi T]]
[[Category: Gheyi, T.]]
[[Category: Iizuka M]]
[[Category: Iizuka, M.]]
[[Category: Romero R]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Russell M]]
[[Category: Romero, R.]]
[[Category: Rutter J]]
[[Category: Russell, M.]]
[[Category: Sauder JM]]
[[Category: Rutter, J.]]
[[Category: Wasserman SR]]
[[Category: Sauder, M J.]]
[[Category: Wasserman, S R.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Cytoplasm]]
[[Category: Drug discovery]]
[[Category: Kinase]]
[[Category: New york sgx research center for structural genomic]]
[[Category: Nucleotide-binding]]
[[Category: Nysgxrc]]
[[Category: Pas kinase]]
[[Category: Pask]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein kinase]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Structural genomic]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 11:31:26 2008''
Retrieved from "https://proteopedia.org/3dls"