1r8k: Difference between revisions

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New page: left|200px<br /><applet load="1r8k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r8k, resolution 2.10Å" /> '''PDXA PROTEIN; NAD-DE...
 
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[[Image:1r8k.jpg|left|200px]]<br /><applet load="1r8k" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1r8k, resolution 2.10&Aring;" />
'''PDXA PROTEIN; NAD-DEPENDENT DEHYDROGENASE/CARBOXYLASE; SUBUNIT OF PYRIDOXINE PHOSPHATE BIOSYNTHETIC PROTEIN PDXJ-PDXA [SALMONELLA TYPHIMURIUM]'''<br />


==About this Structure==
==PDXA PROTEIN; NAD-DEPENDENT DEHYDROGENASE/CARBOXYLASE; SUBUNIT OF PYRIDOXINE PHOSPHATE BIOSYNTHETIC PROTEIN PDXJ-PDXA [SALMONELLA TYPHIMURIUM]==
1R8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with CO, CL and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/4-hydroxythreonine-4-phosphate_dehydrogenase 4-hydroxythreonine-4-phosphate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.262 1.1.1.262] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R8K OCA].
<StructureSection load='1r8k' size='340' side='right'caption='[[1r8k]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
[[Category: 4-hydroxythreonine-4-phosphate dehydrogenase]]
== Structural highlights ==
[[Category: Salmonella typhimurium]]
<table><tr><td colspan='2'>[[1r8k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8K FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Collart, F.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Joachimiak, A.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8k OCA], [https://pdbe.org/1r8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8k RCSB], [https://www.ebi.ac.uk/pdbsum/1r8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8k ProSAT], [https://www.topsan.org/Proteins/MCSG/1r8k TOPSAN]</span></td></tr>
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
</table>
[[Category: Moy, S.]]
== Function ==
[[Category: Osipiuk, J.]]
[https://www.uniprot.org/uniprot/PDXA_SALTY PDXA_SALTY] Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).[HAMAP-Rule:MF_00536]
[[Category: Quartey, P.]]
== Evolutionary Conservation ==
[[Category: CL]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: CO]]
Check<jmol>
[[Category: SO4]]
  <jmolCheckbox>
[[Category: mcsg]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8k_consurf.spt"</scriptWhenChecked>
[[Category: midwest center for structural genomics]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: nad-dependent dehydrogenase/carboxylase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: protein structure initiative]]
  </jmolCheckbox>
[[Category: psi]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8k ConSurf].
[[Category: structural genomics]]
<div style="clear:both"></div>
 
__TOC__
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:21:18 2007''
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Collart F]]
[[Category: Joachimiak A]]
[[Category: Moy S]]
[[Category: Osipiuk J]]
[[Category: Quartey P]]
Retrieved from "https://proteopedia.org/1r8k"