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New page: left|200px<br /> <applet load="2bel" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bel, resolution 2.11Å" /> '''STRUCTURE OF HUMAN ...
 
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[[Image:2bel.gif|left|200px]]<br />
<applet load="2bel" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2bel, resolution 2.11&Aring;" />
'''STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE'''<br />


==About this Structure==
==Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone==
2BEL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, NAP and CBO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]].
<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [https://pdbe.org/2bel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [https://www.ebi.ac.uk/pdbsum/2bel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
== Function ==
[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bel_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abrahmsen, L.]]
[[Category: Abrahmsen L]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Debreczeni, J.E.]]
[[Category: Debreczeni JE]]
[[Category: Delft, F.Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elleby B]]
[[Category: Elleby, B.]]
[[Category: Kavanagh K]]
[[Category: Kavanagh, K.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Sharma S]]
[[Category: Sharma, S.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Svensson S]]
[[Category: Svensson, S.]]
[[Category: Wu X]]
[[Category: Wu, X.]]
[[Category: Von Delft F]]
[[Category: CBO]]
[[Category: CL]]
[[Category: NAP]]
[[Category: drug target]]
[[Category: glucocorticoid activation]]
[[Category: hormone metabolism]]
[[Category: inhibitor]]
[[Category: microsome]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: short-chain dehydrogenase/reductase]]
[[Category: steroid metabolism]]
 
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