1rec: Difference between revisions

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New page: left|200px<br /><applet load="1rec" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rec, resolution 1.9Å" /> '''THREE-DIMENSIONAL STR...
 
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[[Image:1rec.gif|left|200px]]<br /><applet load="1rec" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1rec, resolution 1.9&Aring;" />
'''THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION'''<br />


==Overview==
==THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION==
Recoverin, a recently discovered member of the EF hand superfamily, serves, as a calcium sensor in vision. We report here the crystal structure of, recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF, hands of the protein are arranged in a compact array that contrasts with, the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to, EF hand 3, while EF hand 2 can bind samarium but not calcium in this, crystal form. The other two EF hands have novel structural features that, prevent or impair calcium binding. A concave hydrophobic surface formed by, EF hands 1 and 2 may participate in the read out of calcium signals by, recoverin and its homologs.
<StructureSection load='1rec' size='340' side='right'caption='[[1rec]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1rec]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rec OCA], [https://pdbe.org/1rec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rec RCSB], [https://www.ebi.ac.uk/pdbsum/1rec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rec ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RECO_BOVIN RECO_BOVIN] Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.<ref>PMID:8097896</ref> <ref>PMID:8392055</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1rec_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rec ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1REC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1REC OCA].
*[[Recoverin%2C a calcium-activated myristoyl switch|Recoverin%2C a calcium-activated myristoyl switch]]
 
== References ==
==Reference==
<references/>
Three-dimensional structure of recoverin, a calcium sensor in vision., Flaherty KM, Zozulya S, Stryer L, McKay DB, Cell. 1993 Nov 19;75(4):709-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8242744 8242744]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Flaherty, K.M.]]
[[Category: Flaherty KM]]
[[Category: Mckay, D.B.]]
[[Category: Mckay DB]]
[[Category: Stryer, L.]]
[[Category: Stryer L]]
[[Category: Zozulya, S.]]
[[Category: Zozulya S]]
[[Category: CA]]
[[Category: calcium-binding protein]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:31:15 2007''

Latest revision as of 08:22, 14 February 2024

THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION

1rec, resolution 1.90Å

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