1pl2: Difference between revisions

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{{Seed}}
[[Image:1pl2.png|left|200px]]


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==Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione==
The line below this paragraph, containing "STRUCTURE_1pl2", creates the "Structure Box" on the page.
<StructureSection load='1pl2' size='340' side='right'caption='[[1pl2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABY:N-(4-AMINOBUTANOYL)-S-(4-METHOXYBENZYL)-L-CYSTEINYLGLYCINE'>ABY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
{{STRUCTURE_1pl2| PDB=1pl2 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl2 OCA], [https://pdbe.org/1pl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl2 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl2 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16421451}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16421451 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_16421451}}
 
==About this Structure==
1PL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL2 OCA].
 
==Reference==
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix., Grahn E, Novotny M, Jakobsson E, Gustafsson A, Grehn L, Olin B, Madsen D, Wahlberg M, Mannervik B, Kleywegt GJ, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):197-207. Epub 2006, Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16421451 16421451]
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Grahn, E.]]
[[Category: Grahn E]]
[[Category: Grehn, L.]]
[[Category: Grehn L]]
[[Category: Gustafsson, A.]]
[[Category: Gustafsson A]]
[[Category: Jakobsson, E.]]
[[Category: Jakobsson E]]
[[Category: Kleywegt, G J.]]
[[Category: Kleywegt GJ]]
[[Category: Madsen, D.]]
[[Category: Madsen D]]
[[Category: Mannervik, B.]]
[[Category: Mannervik B]]
[[Category: Olin, B.]]
[[Category: Olin B]]
[[Category: Wahlberg, M.]]
[[Category: Wahlberg M]]
[[Category: Domain1:alpha-beta]]
[[Category: Domain2: alpha-helical]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 12:55:15 2008''

Latest revision as of 05:56, 17 April 2024

Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione

1pl2, resolution 1.80Å

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