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| [[Image:1rid.gif|left|200px]]<br /><applet load="1rid" size="450" color="white" frame="true" align="right" spinBox="true"
| | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1rid was removed. |
| caption="1rid, resolution 2.1Å" />
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| '''Vaccinia Complement Protein in Complex with Heparin'''<br /> | |
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| ==Overview==
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| Vaccinia virus complement control protein (VCP), a homolog of the, regulators of the complement activation family of proteins, inhibits, complement activation through mechanisms similar to human fluid-phase, complement regulators factor H and C4b-binding protein. VCP has a, heparin-binding activity that assists vaccinia in host interactions., Interaction with cell-surface polyanions like heparin is centrally, important in the functioning of fluid-phase complement regulators and is, the basis of host-target discrimination by the alternative pathway. We, report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement, regulation. Properties that VCP shares with fluid-phase complement, regulators suggest that such conformational changes may be of relevance in, the functioning of other complement regulators. Additionally, comparison, of VCP-heparin interactions with potentially similar interactions in, factor H might enable understanding of the structural basis of familial, hemolytic uremic syndrome, attributed to mutational disruption of heparin, and C3b binding by factor H.
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| ==About this Structure==
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| 1RID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA].
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| ==Reference==
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| Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation., Ganesh VK, Smith SA, Kotwal GJ, Murthy KH, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15178763 15178763]
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| [[Category: Single protein]]
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| [[Category: Vaccinia virus]]
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| [[Category: Ganesh, V.K.]]
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| [[Category: Kotwal, G.J.]]
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| [[Category: Murthy, K.H.M.]]
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| [[Category: Smith, S.A.]]
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| [[Category: complement]]
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| [[Category: regulation]]
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| [[Category: scr]]
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| ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:37:19 2007''
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For additional information see 2009, December: at Retractions and Fraud.
REMOVED: The PDB entry 1rid was removed.
