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New page: left|200px<br /><applet load="1rii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rii, resolution 1.70Å" /> '''Crystal structure of...
 
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[[Image:1rii.gif|left|200px]]<br /><applet load="1rii" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1rii, resolution 1.70&Aring;" />
'''Crystal structure of phosphoglycerate mutase from M. Tuberculosis'''<br />


==Overview==
==Crystal structure of phosphoglycerate mutase from M. Tuberculosis==
The single-crystal X-ray structure of phosphoglycerate mutase from, Mycobacterium tuberculosis has been determined at a resolution of 1.70, angstroms. The C-terminal tail of each of the subunits is flexible and, disordered; however, for one of the four chains (chain A) all but five, residues of the chain could be modeled. Noteworthy features of the, structure include the active site and a proline-rich segment in each, monomer forming a short left-handed polyprolyl helix. These segments lie, on the enzyme surface and could conceivably participate in protein-protein, interactions.
<StructureSection load='1rii' size='340' side='right'caption='[[1rii]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1rii]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RII FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rii OCA], [https://pdbe.org/1rii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rii RCSB], [https://www.ebi.ac.uk/pdbsum/1rii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rii ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GPMA_MYCTU GPMA_MYCTU] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1rii_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rii ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The single-crystal X-ray structure of phosphoglycerate mutase from Mycobacterium tuberculosis has been determined at a resolution of 1.70 angstroms. The C-terminal tail of each of the subunits is flexible and disordered; however, for one of the four chains (chain A) all but five residues of the chain could be modeled. Noteworthy features of the structure include the active site and a proline-rich segment in each monomer forming a short left-handed polyprolyl helix. These segments lie on the enzyme surface and could conceivably participate in protein-protein interactions.


==About this Structure==
The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase.,Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):309-15. Epub 2005, Feb 24. PMID:15735341<ref>PMID:15735341</ref>
1RII is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RII OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase., Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):309-15. Epub 2005, Feb 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15735341 15735341]
</div>
<div class="pdbe-citations 1rii" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Phosphoglycerate mutase 3D structures|Phosphoglycerate mutase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Phosphoglycerate mutase]]
[[Category: Chan S]]
[[Category: Single protein]]
[[Category: Eisenberg D]]
[[Category: Chan, S.]]
[[Category: Mueller P]]
[[Category: Eisenberg, D.]]
[[Category: Pashkova I]]
[[Category: Mueller, P.]]
[[Category: Perry J]]
[[Category: Pashkova, I.]]
[[Category: Sawaya MR]]
[[Category: Perry, J.]]
[[Category: Wu Y]]
[[Category: Sawaya, M.R.]]
[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]
[[Category: Wu, Y.]]
[[Category: GOL]]
[[Category: phosphoglyerate mutase]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: sh3 domain binding]]
[[Category: structural genomics]]
[[Category: tb structural genomics consortium]]
[[Category: tbsgc]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:37:28 2007''

Latest revision as of 06:04, 23 August 2023

Crystal structure of phosphoglycerate mutase from M. Tuberculosis

1rii, resolution 1.70Å

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