Induced fit: Difference between revisions
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[[Image:Induced fit.gif|frame|Morph of hexokinase in the open [[3o80]] and glucose-bound closed [[3o8m]] conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.]] | |||
[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classic example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] in the picture at right. | |||
==History of the concept== | |||
Induced fit was suggested by Koshland in 1958 <ref> DOI:10.1002/anie.199423751</ref>, providing an alternative to the lock-and-key binding model that Emil Fischer proposed in 1899 <ref>DOI:10.1002/cber.18940270364</ref>. | |||
==Interactive examples== | |||
<StructureSection load='' size='350' side='right' caption='' scene=''> | |||
This is a [[morphs|morph]] of the <scene name='31/318562/Hexokinase/3'>closed and open form of hexokinase</scene> (be patient when loading this). The first and the last frame of the animation are models based on crystallographic data while the intermediate states are somewhat arbitrary, but chosen to show a smooth transition between conformations. | |||
<jmol> | |||
<jmolRadioGroup> | |||
<item> | |||
<script>anim off;model 1</script> | |||
<text>Open</text> | |||
</item> | |||
<item> | |||
<script>anim off;model 11</script> | |||
<text>Closed</text> | |||
</item> | |||
<item> | |||
<script>anim on;</script> | |||
<text>Animated</text> | |||
<checked>true</checked> | |||
</item> | |||
</jmolRadioGroup> | |||
</jmol> | |||
</StructureSection> | |||
==See Also== | |||
*A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]]. | |||
== References == | |||
<references/> | |||
