2znr: Difference between revisions

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{{Seed}}
[[Image:2znr.png|left|200px]]


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==Crystal structure of the DUB domain of human AMSH-LP==
The line below this paragraph, containing "STRUCTURE_2znr", creates the "Structure Box" on the page.
<StructureSection load='2znr' size='340' side='right'caption='[[2znr]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2znr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2znr|  PDB=2znr  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znr OCA], [https://pdbe.org/2znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znr RCSB], [https://www.ebi.ac.uk/pdbsum/2znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znr ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the DUB domain of human AMSH-LP===
== Function ==
 
[https://www.uniprot.org/uniprot/STALP_HUMAN STALP_HUMAN] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.<ref>PMID:18758443</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_18758443}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/2znr_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_18758443}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2ZNR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNR OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2znr ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains., Sato Y, Yoshikawa A, Yamagata A, Mimura H, Yamashita M, Ookata K, Nureki O, Iwai K, Komada M, Fukai S, Nature. 2008 Sep 18;455(7211):358-62. Epub 2008 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18758443 18758443]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ubiquitin thiolesterase]]
[[Category: Azusa Y]]
[[Category: Azusa, Y.]]
[[Category: Fukai S]]
[[Category: Fukai, S.]]
[[Category: Iwai K]]
[[Category: Iwai, K.]]
[[Category: Komada M]]
[[Category: Komada, M.]]
[[Category: Mimura H]]
[[Category: Mimura, H.]]
[[Category: Nureki O]]
[[Category: Nureki, O.]]
[[Category: Ookata K]]
[[Category: Ookata, K.]]
[[Category: Sato Y]]
[[Category: Sato, Y.]]
[[Category: Wang X]]
[[Category: Wang, X.]]
[[Category: Yamagata A]]
[[Category: Yamagata, A.]]
[[Category: Yamashita M]]
[[Category: Yamashita, M.]]
[[Category: Alternative splicing]]
[[Category: Hydrolase]]
[[Category: Metal binding protein]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Protease]]
[[Category: Ubl conjugation pathway]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 09:13:14 2008''
Retrieved from "https://proteopedia.org/2znr"