3eil: Difference between revisions

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New page: '''Unreleased structure''' The entry 3eil is ON HOLD Authors: Millonig, H., Pous, J., Campos, L.J., Subirana, J.A. Description: Structure of B-DNA d(CGTTAATTAACG)2 in the presence of M...
 
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'''Unreleased structure'''


The entry 3eil is ON HOLD
==Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese==
<StructureSection load='3eil' size='340' side='right'caption='[[3eil]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3eil]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EIL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eil OCA], [https://pdbe.org/3eil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eil RCSB], [https://www.ebi.ac.uk/pdbsum/3eil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eil ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We present the structure of the duplex formed by a fragment of auto-complementary DNA with the sequence d(CGTTAATTAACG). The structure was determined by X-ray crystallography. Up to date it is the first structure presenting the interaction between a DNA oligonucleotide and manganese ions. The presence of Mn2+ creates bonds among the N7 atom of guanines and phosphates. These bonds stabilize and determine the crystallographic network in a P3(2) space group, unusual in oligonucleotide crystals. The crystal structure observed is compared with those found in the presence of Mg2+, Ca2+ and Ni2+, which show different kinds of interactions. The double helices show end-to-end interactions, in a manner that the terminal guanines interact with the minor groove of the neighboring duplex, while the terminal cytosines are disordered. We have chosen this sequence since it contains a TTAA repeat. Such repeats are very rare in all genomes. We suggest that this sequence may be very susceptible to the formation of closely spaced thymine dimers.


Authors: Millonig, H., Pous, J., Campos, L.J., Subirana, J.A.
The interaction of manganese ions with DNA.,Millonig H, Pous J, Gouyette C, Subirana JA, Campos JL J Inorg Biochem. 2009 Jun;103(6):876-80. Epub 2009 Mar 25. PMID:19375803<ref>PMID:19375803</ref>


Description: Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:16:47 2008''
<div class="pdbe-citations 3eil" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Campos LJ]]
[[Category: Millonig H]]
[[Category: Pous J]]
[[Category: Subirana JA]]
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