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New page: left|200px<br /><applet load="1rsy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rsy, resolution 1.9Å" /> '''STRUCTURE OF THE FIRS...
 
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[[Image:1rsy.gif|left|200px]]<br /><applet load="1rsy" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1rsy, resolution 1.9&Aring;" />
'''STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD'''<br />


==Overview==
==STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD==
C2 domains are regulatory sequence motifs that occur widely in nature., Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+, regulation of exocytosis, contains two C2 domains, the first of which acts, as a Ca2+ sensor. We now describe the three-dimensional structure of this, C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free, forms. The C2 polypeptide forms an eight-stranded beta sandwich, constructed around a conserved four-stranded motif designated as a C2 key., Ca2+ binds in a cup-shaped depression between two polypeptide loops, located at the N- and C-termini of the C2-key motif.
<StructureSection load='1rsy' size='340' side='right'caption='[[1rsy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1rsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsy OCA], [https://pdbe.org/1rsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsy RCSB], [https://www.ebi.ac.uk/pdbsum/1rsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rs/1rsy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rsy ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1RSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RSY OCA].
*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold., Sutton RB, Davletov BA, Berghuis AM, Sudhof TC, Sprang SR, Cell. 1995 Mar 24;80(6):929-38. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7697723 7697723]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Sprang SR]]
[[Category: Sprang, S.R.]]
[[Category: Sutton RB]]
[[Category: Sutton, R.B.]]
[[Category: SO4]]
[[Category: calcium/phospholipid binding protein]]
 
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