2cui: Difference between revisions

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{{Seed}}
[[Image:2cui.png|left|200px]]


<!--
==Solution structure of the 31st fibronectin type III domain of the human tenascin X==
The line below this paragraph, containing "STRUCTURE_2cui", creates the "Structure Box" on the page.
<StructureSection load='2cui' size='340' side='right'caption='[[2cui]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [https://pdbe.org/2cui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [https://www.ebi.ac.uk/pdbsum/2cui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [https://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
{{STRUCTURE_2cui|  PDB=2cui  |  SCENE=  }}
</table>
 
== Disease ==
===Solution structure of the 31st fibronectin type III domain of the human tenascin X===
[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[https://omim.org/entry/606408 606408]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
 
== Function ==
 
[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>
==Disease==
== Evolutionary Conservation ==
Known disease associated with this structure: Ehlers-Danlos due to tenascin X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600985 600985]], Ehlers-Danlos syndrome, hypermobility type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600985 600985]]
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2CUI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cui_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cui ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Ohnishi, S.]]
[[Category: Ohnishi S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Extracellular matirx]]
[[Category: Fibronectin type iii domain]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Tenascin x precursor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 16:34:43 2008''

Latest revision as of 11:31, 22 May 2024

Solution structure of the 31st fibronectin type III domain of the human tenascin X

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