2fc6: Difference between revisions

Latest revision as of 16:35, 13 December 2023

Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)

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[1] De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED. In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. J Biol Chem. 2003 Apr 18;278(16):14306-12. PMID:12562764 doi:10.1074/jbc.M210502200

[2] Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çağlayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar;49(3):457-464. PMID:28092684 doi:10.1038/ng.3762

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-{{Seed}}
-[[Image:2fc6.png|left|200px]]
-<!--
+==Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)==
-The line below this paragraph, containing "STRUCTURE_2fc6", creates the "Structure Box" on the page.
+<StructureSection load='2fc6' size='340' side='right'caption='[[2fc6]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2fc6|  PDB=2fc6  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc6 OCA], [https://pdbe.org/2fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc6 TOPSAN]</span></td></tr>
+</table>
-===Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)===
+== Disease ==
+[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Pontocerebellar hypoplasia type 7. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
-==About this Structure==
+[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).<ref>PMID:12562764</ref> <ref>PMID:28092684</ref>
-FC6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA].
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Dang, W.]]
+[[Category: Dang W]]
-[[Category: Inoue, M.]]
+[[Category: Inoue M]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Muto, Y.]]
+[[Category: Muto Y]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Terada, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nmr]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Structure genomic]]
-[[Category: Zf-ccch domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 17:40:43 2008''

2fc6: Difference between revisions

Latest revision as of 16:35, 13 December 2023

Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)

Structural highlights

Disease

Function

References

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