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New page: left|200px<br /><applet load="1s22" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s22, resolution 1.60Å" /> '''Absolute Stereochemi...
 
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[[Image:1s22.gif|left|200px]]<br /><applet load="1s22" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1s22, resolution 1.60&Aring;" />
'''Absolute Stereochemistry of Ulapualide A'''<br />


==Overview==
==Absolute Stereochemistry of Ulapualide A==
[structure: see text] The structure of ulapualide A (1) has been solved by, X-ray crystallography in a complex with G-actin. The stereochemical, configuration was assigned as 3S,9S,22S,23R,24S,26S,27S,31R,32R,33R.
<StructureSection load='1s22' size='340' side='right'caption='[[1s22]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1s22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S22 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=ULA:ULAPUALIDE+A'>ULA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s22 OCA], [https://pdbe.org/1s22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s22 RCSB], [https://www.ebi.ac.uk/pdbsum/1s22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s22 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
[structure: see text] The structure of ulapualide A (1) has been solved by X-ray crystallography in a complex with G-actin. The stereochemical configuration was assigned as 3S,9S,22S,23R,24S,26S,27S,31R,32R,33R.


==About this Structure==
Absolute stereochemistry of ulapualide A.,Allingham JS, Tanaka J, Marriott G, Rayment I Org Lett. 2004 Feb 19;6(4):597-9. PMID:14961632<ref>PMID:14961632</ref>
1S22 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with CA, ATP, ULA and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S22 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Absolute stereochemistry of ulapualide A., Allingham JS, Tanaka J, Marriott G, Rayment I, Org Lett. 2004 Feb 19;6(4):597-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14961632 14961632]
</div>
<div class="pdbe-citations 1s22" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Actin 3D structures|Actin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Single protein]]
[[Category: Allingham JS]]
[[Category: Allingham, J.S.]]
[[Category: Marriott G]]
[[Category: Marriott, G.]]
[[Category: Rayment I]]
[[Category: Rayment, I.]]
[[Category: Tanaka J]]
[[Category: Tanaka, J.]]
[[Category: ATP]]
[[Category: CA]]
[[Category: EDO]]
[[Category: ULA]]
[[Category: actin; trisoxazole; macrolide; toxin; ulapualide; stereochemistry]]
 
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Retrieved from "https://proteopedia.org/1s22"