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New page: left|200px<br /><applet load="1s7o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s7o, resolution 2.31Å" /> '''Crystal structure of...
 
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[[Image:1s7o.gif|left|200px]]<br /><applet load="1s7o" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1s7o, resolution 2.31&Aring;" />
'''Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes'''<br />


==Overview==
==Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes==
The crystal structure of the putative DNA-binding protein SP_1288, (gi/15675166, also listed as gi/28895954) from Streptococcus pyogenes has, been determined by X-ray crystallography to a resolution of 2.3 A using, anomalous diffraction data at the Se peak wavelength. SP_1288 belongs to a, family of proteins whose cellular function is associated with the signal, recognition particle; no structural information has been available until, now about the members of the family. Crystallographic analysis revealed, that the overall fold of SP_1288 consists exclusively of alpha-helices and, that 75% of the structure has good similarity to domain 4 of the sigma, subunit of RNA polymerase. This suggests its possible involvement in the, biochemical function of transcription initiation, which includes, interaction with DNA.
<StructureSection load='1s7o' size='340' side='right'caption='[[1s7o]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1s7o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M3 Streptococcus pyogenes serotype M3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S7O FirstGlance]. <br>
1S7O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7o OCA], [https://pdbe.org/1s7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s7o RCSB], [https://www.ebi.ac.uk/pdbsum/1s7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7o ProSAT], [https://www.topsan.org/Proteins/BSGC/1s7o TOPSAN]</span></td></tr>
==Reference==
</table>
Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes., Oganesyan V, Pufan R, DeGiovanni A, Yokota H, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1266-71. Epub 2004, Jun 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15213388 15213388]
== Function ==
[[Category: Single protein]]
[https://www.uniprot.org/uniprot/Y842_STRP3 Y842_STRP3] Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein (By similarity).
[[Category: Streptococcus pyogenes]]
== Evolutionary Conservation ==
[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: DeGiovanni, A.]]
Check<jmol>
[[Category: Kim, R.]]
  <jmolCheckbox>
[[Category: Kim, S.H.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7o_consurf.spt"</scriptWhenChecked>
[[Category: Oganesyan, V.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Pufan, R.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Yokota, H.]]
  </jmolCheckbox>
[[Category: berkeley structural genomics center]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s7o ConSurf].
[[Category: bsgc]]
<div style="clear:both"></div>
[[Category: protein structure initiative]]
__TOC__
[[Category: psi]]
</StructureSection>
[[Category: putative dna binding protein; structural genomics]]
[[Category: Large Structures]]
[[Category: rna polymerase sigma factor]]
[[Category: Streptococcus pyogenes serotype M3]]
[[Category: signal recognition particle]]
[[Category: DeGiovanni A]]
[[Category: structure funded by nih]]
[[Category: Kim R]]
[[Category: upf0122]]
[[Category: Kim S-H]]
[[Category: x-rat crystallography]]
[[Category: Oganesyan V]]
 
[[Category: Pufan R]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:10:28 2007''
[[Category: Yokota H]]
Retrieved from "https://proteopedia.org/1s7o"