1sdb: Difference between revisions
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New page: left|200px<br /><applet load="1sdb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sdb, resolution 1.65Å" /> '''PORCINE DESB1-2 DESP... |
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== | ==PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN== | ||
Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures | <StructureSection load='1sdb' size='340' side='right'caption='[[1sdb]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1sdb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SDB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sdb OCA], [https://pdbe.org/1sdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sdb RCSB], [https://www.ebi.ac.uk/pdbsum/1sdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sdb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility. | |||
Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution.,Diao JS, Wan ZL, Chang WR, Liang DC Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880<ref>PMID:15299880</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 1sdb" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Insulin 3D Structures|Insulin 3D Structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Diao | [[Category: Diao J-S]] | ||
[[Category: Liang | [[Category: Liang D-C]] | ||
Latest revision as of 21:35, 28 June 2023
PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN
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