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New page: left|200px<br /><applet load="1sfp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sfp, resolution 1.90Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1sfp.gif|left|200px]]<br /><applet load="1sfp" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1sfp, resolution 1.90&Aring;" />
'''CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY'''<br />


==Overview==
==CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY==
Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins, involved in sperm-egg binding and display a single CUB domain, architecture. We report the crystal structures of porcine seminal plasma, PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine, aSFP at 2.4 A and 1.9 A resolution respectively.
<StructureSection load='1sfp' size='340' side='right'caption='[[1sfp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1sfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SFP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sfp OCA], [https://pdbe.org/1sfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sfp RCSB], [https://www.ebi.ac.uk/pdbsum/1sfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sfp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPAD1_BOVIN SPAD1_BOVIN] Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sf/1sfp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sfp ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins involved in sperm-egg binding and display a single CUB domain architecture. We report the crystal structures of porcine seminal plasma PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine aSFP at 2.4 A and 1.9 A resolution respectively.


==About this Structure==
The crystal structures of two spermadhesins reveal the CUB domain fold.,Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:9334740<ref>PMID:9334740</ref>
1SFP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SFP OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
The crystal structures of two spermadhesins reveal the CUB domain fold., Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ, Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9334740 9334740]
</div>
<div class="pdbe-citations 1sfp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Calvete, J.J.]]
[[Category: Calvete JJ]]
[[Category: Carvalho, A.L.]]
[[Category: Carvalho AL]]
[[Category: Dias, J.M.]]
[[Category: Dias JM]]
[[Category: Kolln, I.]]
[[Category: Kolln I]]
[[Category: Romao, M.J.]]
[[Category: Romao MJ]]
[[Category: Romero, A.]]
[[Category: Romero A]]
[[Category: Sanz, L.]]
[[Category: Sanz L]]
[[Category: Topfer-Petersen, E.]]
[[Category: Topfer-Petersen E]]
[[Category: Varela, P.F.]]
[[Category: Varela PF]]
[[Category: acidic seminal fluid protein]]
[[Category: asfp]]
[[Category: bovine seminal plasma protein]]
[[Category: cub domain]]
[[Category: growth factor]]
[[Category: spermadhesin]]
[[Category: x-ray crystal structure]]
 
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