3epn: Difference between revisions
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New page: '''Unreleased structure''' The entry 3epn is ON HOLD Authors: Li, S., Chatterjee, A., Zhang, Y., Grove, T.L., Lee, M., Krebs, C., Booker, S.J., Begley, T.P., Ealick, S.E. Description: ... |
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==Crystal structure of Caulobacter crescentus ThiC complexed with imidazole ribonucleotide== | |||
<StructureSection load='3epn' size='340' side='right'caption='[[3epn]], [[Resolution|resolution]] 2.11Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3epn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IRN:1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE'>IRN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epn OCA], [https://pdbe.org/3epn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epn RCSB], [https://www.ebi.ac.uk/pdbsum/3epn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/THIC_CAUVC THIC_CAUVC] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18953358</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epn_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epn ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caulobacter vibrioides]] | |||
[[Category: Large Structures]] | |||
[[Category: Begley TP]] | |||
[[Category: Booker SJ]] | |||
[[Category: Chatterjee A]] | |||
[[Category: Ealick SE]] | |||
[[Category: Grove TL]] | |||
[[Category: Krebs C]] | |||
[[Category: Lee M]] | |||
[[Category: Li S]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 09:48, 21 February 2024
Crystal structure of Caulobacter crescentus ThiC complexed with imidazole ribonucleotide
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