1t1t: Difference between revisions
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New page: left|200px<br /><applet load="1t1t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t1t" /> '''Solution Structure of Kurtoxin'''<br /> ==A... |
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== | ==Solution Structure of Kurtoxin== | ||
<StructureSection load='1t1t' size='340' side='right'caption='[[1t1t]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1t1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1t OCA], [https://pdbe.org/1t1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1t RCSB], [https://www.ebi.ac.uk/pdbsum/1t1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KURT_PARTR KURT_PARTR] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A. Also binds to Cav3.1/CACNA1G and Cav3.2/CACNA1H T-type calcium channels with high affinity and inhibits the channels by modifying voltage-dependent gating. Another study (PubMed:11896142) shows that it also targets neuronal high-threshold calcium channels, including P-type, N-type, and L-type calcium channels (Cav), and others that still are unidentified pharmacologically.<ref>PMID:10196582</ref> <ref>PMID:11896142</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1t_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1t ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Parabuthus transvaalicus]] | [[Category: Parabuthus transvaalicus]] | ||
[[Category: Cho EM]] | |||
[[Category: Cho | [[Category: Eu YJ]] | ||
[[Category: Eu | [[Category: Kim JI]] | ||
[[Category: Kim | [[Category: Kohno T]] | ||
[[Category: Kohno | [[Category: Lee CW]] | ||
[[Category: Lee | [[Category: Min HJ]] | ||
[[Category: Min | |||
Latest revision as of 04:54, 17 October 2024
Solution Structure of Kurtoxin
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