2zpl: Difference between revisions

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{{Seed}}
[[Image:2zpl.jpg|left|200px]]


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==Crystal structure analysis of PDZ domain A==
The line below this paragraph, containing "STRUCTURE_2zpl", creates the "Structure Box" on the page.
<StructureSection load='2zpl' size='340' side='right'caption='[[2zpl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zpl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZPL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
{{STRUCTURE_2zpl|  PDB=2zpl  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zpl OCA], [https://pdbe.org/2zpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zpl RCSB], [https://www.ebi.ac.uk/pdbsum/2zpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zpl ProSAT]</span></td></tr>
 
</table>
===Crystal structure analysis of PDZ domain A===
== Function ==
 
[https://www.uniprot.org/uniprot/RSEP_ECOLI RSEP_ECOLI] A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue "Val-148" of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane.<ref>PMID:11750129</ref> <ref>PMID:12183368</ref> <ref>PMID:12183369</ref> <ref>PMID:15496982</ref> <ref>PMID:18268014</ref> <ref>PMID:21810987</ref> <ref>PMID:18945679</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2ZPL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPL OCA].  
Check<jmol>
[[Category: Escherichia coli]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/2zpl_consurf.spt"</scriptWhenChecked>
[[Category: Inaba, K.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Suzuki, M.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Hydrolase]]
  </jmolCheckbox>
[[Category: Inner membrane]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zpl ConSurf].
[[Category: Membrane]]
<div style="clear:both"></div>
[[Category: Membrane protein]]
== References ==
[[Category: Metal-binding]]
<references/>
[[Category: Metalloprotease]]
__TOC__
[[Category: Metalloproteinase]]
</StructureSection>
[[Category: Pdz-domain]]
[[Category: Escherichia coli K-12]]
[[Category: Protease]]
[[Category: Large Structures]]
[[Category: Transmembrane]]
[[Category: Inaba K]]
[[Category: Zinc]]
[[Category: Suzuki M]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 22 10:38:58 2008''
Retrieved from "https://proteopedia.org/2zpl"