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New page: left|200px<br /><applet load="1tia" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tia, resolution 2.1Å" /> '''AN UNUSUAL BURIED POL...
 
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[[Image:1tia.gif|left|200px]]<br /><applet load="1tia" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1tia, resolution 2.1&Aring;" />
'''AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES'''<br />


==Overview==
==AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES==
The stability of globular proteins arises largely from the burial of, non-polar amino acids in their interior. These residues are efficiently, packed to eliminate energetically unfavorable cavities. Contrary to these, observations, high resolution X-ray crystallographic analyses of four, homologous lipases from filamentous fungi reveal an alpha/beta fold which, contains a buried conserved constellation of charged and polar side chains, with associated cavities containing ordered water molecules. It is, possible that this structural arrangement plays an important role in, interfacial catalysis.
<StructureSection load='1tia' size='340' side='right'caption='[[1tia]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penicillium_camemberti Penicillium camemberti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TIA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tia OCA], [https://pdbe.org/1tia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tia RCSB], [https://www.ebi.ac.uk/pdbsum/1tia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tia ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDLA_PENCA MDLA_PENCA] Hydrolyzes mono- and diacylglycerol but not triacylglycerol.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ti/1tia_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tia ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1TIA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Penicillium_camemberti Penicillium camemberti]. Active as [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TIA OCA].
*[[Lipase 3D Structures|Lipase 3D Structures]]
 
__TOC__
==Reference==
</StructureSection>
An unusual buried polar cluster in a family of fungal lipases., Derewenda U, Swenson L, Green R, Wei Y, Dodson GG, Yamaguchi S, Haas MJ, Derewenda ZS, Nat Struct Biol. 1994 Jan;1(1):36-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7656005 7656005]
[[Category: Large Structures]]
[[Category: Penicillium camemberti]]
[[Category: Penicillium camemberti]]
[[Category: Single protein]]
[[Category: Derewenda U]]
[[Category: Triacylglycerol lipase]]
[[Category: Derewenda ZS]]
[[Category: Derewenda, U.]]
[[Category: Swenson L]]
[[Category: Derewenda, Z.S.]]
[[Category: Wei Y]]
[[Category: Swenson, L.]]
[[Category: Yamaguchi S]]
[[Category: Wei, Y.]]
[[Category: Yamaguchi, S.]]
[[Category: hydrolase(carboxylic esterase)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:17:15 2007''

Latest revision as of 08:39, 14 February 2024

AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES

1tia, resolution 2.10Å

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