3bjy: Difference between revisions

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{{Seed}}
[[Image:3bjy.jpg|left|200px]]


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==Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide==
The line below this paragraph, containing "STRUCTURE_3bjy", creates the "Structure Box" on the page.
<StructureSection load='3bjy' size='340' side='right'caption='[[3bjy]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bjy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BJY FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCP:2-DEOXYCYTIDINE-5-TRIPHOSPHATE'>DCP</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P:2-DEOXY-N1,N2-PROPANO+GUANOSINE+MONOPHOSPHATE'>P</scene></td></tr>
{{STRUCTURE_3bjy| PDB=3bjy |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjy OCA], [https://pdbe.org/3bjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bjy RCSB], [https://www.ebi.ac.uk/pdbsum/3bjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REV1_YEAST REV1_YEAST] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.<ref>PMID:8751446</ref> <ref>PMID:11316789</ref> <ref>PMID:16452144</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bjy ConSurf].
<div style="clear:both"></div>


===Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18275815}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18275815 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_18275815}}
 
==About this Structure==
3BJY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJY OCA].
 
==Reference==
Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase., Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK, Structure. 2008 Feb;16(2):239-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18275815 18275815]
[[Category: Protein complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Aggarwal, A K.]]
[[Category: Aggarwal AK]]
[[Category: Johnson, R E.]]
[[Category: Johnson RE]]
[[Category: Nair, D T.]]
[[Category: Nair DT]]
[[Category: Prakash, L.]]
[[Category: Prakash L]]
[[Category: Prakash, S.]]
[[Category: Prakash S]]
[[Category: Adduct]]
[[Category: Bypass]]
[[Category: Dna damage]]
[[Category: Dna polymerase]]
[[Category: Dna repair]]
[[Category: Dna synthesis]]
[[Category: Dna-binding]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleus]]
[[Category: Protein-dna complex]]
[[Category: Transferase]]
[[Category: Transferase/dna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 29 10:53:58 2008''
Retrieved from "https://proteopedia.org/3bjy"