3epo: Difference between revisions
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==Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P== | |||
<StructureSection load='3epo' size='340' side='right'caption='[[3epo]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3epo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MP5:(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL+DIHYDROGEN+PHOSPHATE'>MP5</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epo OCA], [https://pdbe.org/3epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epo RCSB], [https://www.ebi.ac.uk/pdbsum/3epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/THIC_CAUVC THIC_CAUVC] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18953358</ref> | |||
== Evolutionary Conservation == | |||
== | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epo_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epo ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caulobacter vibrioides]] | [[Category: Caulobacter vibrioides]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Begley | [[Category: Begley TP]] | ||
[[Category: Booker | [[Category: Booker SJ]] | ||
[[Category: Chatterjee | [[Category: Chatterjee A]] | ||
[[Category: Ealick | [[Category: Ealick SE]] | ||
[[Category: Grove | [[Category: Grove TL]] | ||
[[Category: Krebs | [[Category: Krebs C]] | ||
[[Category: Lee | [[Category: Lee M]] | ||
[[Category: Li | [[Category: Li S]] | ||
[[Category: Zhang | [[Category: Zhang Y]] | ||
Latest revision as of 09:48, 21 February 2024
Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P
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