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New page: left|200px<br /><applet load="1tnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tnd, resolution 2.2Å" /> '''THE 2.2 ANGSTROMS CRY...
 
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[[Image:1tnd.gif|left|200px]]<br /><applet load="1tnd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1tnd, resolution 2.2&Aring;" />
'''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''<br />


==Overview==
==THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S==
The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP, gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft, between a domain structurally homologous to small GTPases and a helical, domain unique to heterotrimeric G proteins. The structure, when combined, with biochemical and genetic studies, suggests: how an activated receptor, might open this cleft to allow nucleotide exchange; a mechanism for, GTP-induced changes in effector and receptor binding surfaces; and a, mechanism for GTPase activity not evident from previous data.
<StructureSection load='1tnd' size='340' side='right'caption='[[1tnd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tnd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TND FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tnd OCA], [https://pdbe.org/1tnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tnd RCSB], [https://www.ebi.ac.uk/pdbsum/1tnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tnd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tn/1tnd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tnd ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1TND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with MG, CAC and GSP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TND OCA].
*[[Transducin 3D structures|Transducin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8259210 8259210]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hamm, H.E.]]
[[Category: Hamm HE]]
[[Category: Noel, J.P.]]
[[Category: Noel JP]]
[[Category: Sigler, P.B.]]
[[Category: Sigler PB]]
[[Category: CAC]]
[[Category: GSP]]
[[Category: MG]]
[[Category: binding protein(gtp)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:25:55 2007''

Latest revision as of 08:40, 14 February 2024

THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

1tnd, resolution 2.20Å

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