2i7p: Difference between revisions

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{{Seed}}
[[Image:2i7p.png|left|200px]]


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==Crystal structure of human PANK3 in complex with AcCoA==
The line below this paragraph, containing "STRUCTURE_2i7p", creates the "Structure Box" on the page.
<StructureSection load='2i7p' size='340' side='right'caption='[[2i7p]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2i7p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
{{STRUCTURE_2i7p| PDB=2i7p |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7p OCA], [https://pdbe.org/2i7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7p RCSB], [https://www.ebi.ac.uk/pdbsum/2i7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANK3_HUMAN PANK3_HUMAN] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7p ConSurf].
<div style="clear:both"></div>


===Crystal structure of human PANK3 in complex with AcCoA===
==See Also==
 
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_17631502}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17631502 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17631502}}
 
==About this Structure==
2I7P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7P OCA].
 
==Reference==
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder., Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW, J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17631502 17631502]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pantothenate kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Finerty P]]
[[Category: Finerty, P.]]
[[Category: Hong BS]]
[[Category: Hong, B S.]]
[[Category: Loppnau P]]
[[Category: Loppnau, P.]]
[[Category: Park HW]]
[[Category: Park, H W.]]
[[Category: Shen L]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Shen, L.]]
[[Category: Tempel W]]
[[Category: Sundstrom, M.]]
[[Category: Wang L]]
[[Category: Tempel, W.]]
[[Category: Weigelt J]]
[[Category: Wang, L.]]
[[Category: Weigelt, J.]]
[[Category: Pank]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  5 10:47:38 2008''
Retrieved from "https://proteopedia.org/2i7p"