3eam: Difference between revisions

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{{Seed}}
[[Image:3eam.jpg|left|200px]]


<!--
==An open-pore structure of a bacterial pentameric ligand-gated ion channel==
The line below this paragraph, containing "STRUCTURE_3eam", creates the "Structure Box" on the page.
<StructureSection load='3eam' size='340' side='right'caption='[[3eam]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3eam]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
{{STRUCTURE_3eam| PDB=3eam |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eam OCA], [https://pdbe.org/3eam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eam RCSB], [https://www.ebi.ac.uk/pdbsum/3eam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eam ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eam_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eam ConSurf].
<div style="clear:both"></div>


===An open-pore structure of a bacterial pentameric ligand-gated ion channel===
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
 
== References ==
==About this Structure==
<references/>
3EAM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAM OCA].
__TOC__
</StructureSection>
[[Category: Gloeobacter violaceus]]
[[Category: Gloeobacter violaceus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Baaden, M.]]
[[Category: Baaden M]]
[[Category: Bocquet, N.]]
[[Category: Bocquet N]]
[[Category: Changeux, J P.]]
[[Category: Changeux JP]]
[[Category: Corringer, P J.]]
[[Category: Corringer PJ]]
[[Category: Delarue, M.]]
[[Category: Delarue M]]
[[Category: Nury, H.]]
[[Category: Le Poupon C]]
[[Category: Poupon, C Le.]]
[[Category: Nury H]]
[[Category: Membrane protein]]
[[Category: Pentameric ligand-gated ion-channel]]
[[Category: Transport protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  5 12:54:06 2008''
Retrieved from "https://proteopedia.org/3eam"