3f0w: Difference between revisions
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==Human NUMB-like protein, phosphotyrosine interaction domain== | |||
<StructureSection load='3f0w' size='340' side='right'caption='[[3f0w]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3f0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0w OCA], [https://pdbe.org/3f0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0w RCSB], [https://www.ebi.ac.uk/pdbsum/3f0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0w ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NUMBL_HUMAN NUMBL_HUMAN] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.<ref>PMID:18299187</ref> <ref>PMID:20079715</ref> | |||
== Evolutionary Conservation == | |||
== | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/3f0w_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f0w ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Andersson | [[Category: Andersson J]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Berglund H]] | |||
[[Category: Berglund | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: Collins R]] | ||
[[Category: | [[Category: D Busam R]] | ||
[[Category: | [[Category: Dahlgren LG]] | ||
[[Category: Dahlgren | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Flodin S]] | ||
[[Category: Flodin | [[Category: Flores A]] | ||
[[Category: Flores | [[Category: Graslund S]] | ||
[[Category: Graslund | [[Category: Hammarstrom M]] | ||
[[Category: Hammarstrom | [[Category: Johansson A]] | ||
[[Category: Johansson | [[Category: Johansson I]] | ||
[[Category: Johansson | [[Category: Karlberg T]] | ||
[[Category: Karlberg | [[Category: Kotenyova T]] | ||
[[Category: Kotenyova | [[Category: Lehtio L]] | ||
[[Category: Lehtio | [[Category: Moche M]] | ||
[[Category: Moche | [[Category: Nilsson ME]] | ||
[[Category: Nilsson | [[Category: Nordlund P]] | ||
[[Category: Nordlund | [[Category: Nyman T]] | ||
[[Category: Nyman | [[Category: Persson C]] | ||
[[Category: Persson | [[Category: Sagemark J]] | ||
[[Category: Schueler H]] | |||
[[Category: Sagemark | [[Category: Thorsell AG]] | ||
[[Category: Schueler | [[Category: Tresaugues L]] | ||
[[Category: Thorsell | [[Category: Van Den Berg S]] | ||
[[Category: Tresaugues | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Welin M]] | ||
[[Category: | [[Category: Wikstrom M]] | ||
[[Category: | [[Category: Wisniewska M]] | ||
[[Category: | |||
[[Category: | |||
Latest revision as of 15:25, 1 November 2023
Human NUMB-like protein, phosphotyrosine interaction domain
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Large Structures
- Andersson J
- Arrowsmith CH
- Berglund H
- Bountra C
- Collins R
- D Busam R
- Dahlgren LG
- Edwards AM
- Flodin S
- Flores A
- Graslund S
- Hammarstrom M
- Johansson A
- Johansson I
- Karlberg T
- Kotenyova T
- Lehtio L
- Moche M
- Nilsson ME
- Nordlund P
- Nyman T
- Persson C
- Sagemark J
- Schueler H
- Thorsell AG
- Tresaugues L
- Van Den Berg S
- Weigelt J
- Welin M
- Wikstrom M
- Wisniewska M
