2e1o: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2e1o.png|left|200px]]


<!--
==Solution structure of RSGI RUH-028, a homeobox domain from human cDNA==
The line below this paragraph, containing "STRUCTURE_2e1o", creates the "Structure Box" on the page.
<StructureSection load='2e1o' size='340' side='right'caption='[[2e1o]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E1O FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [https://pdbe.org/2e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [https://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr>
{{STRUCTURE_2e1o|  PDB=2e1o  |  SCENE=  }}
</table>
 
== Function ==
===Solution structure of RSGI RUH-028, a homeobox domain from human cDNA===
[https://www.uniprot.org/uniprot/HHEX_HUMAN HHEX_HUMAN] Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2E1O is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/2e1o_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e1o ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Abe, T.]]
[[Category: Large Structures]]
[[Category: Hirota, H.]]
[[Category: Abe T]]
[[Category: Kawaii, S.]]
[[Category: Hirota H]]
[[Category: Kigawa, T.]]
[[Category: Kawaii S]]
[[Category: Koshiba, S.]]
[[Category: Kigawa T]]
[[Category: Nakamura, A.]]
[[Category: Koshiba S]]
[[Category: Nameki, N.]]
[[Category: Nakamura A]]
[[Category: Ohnishi, S.]]
[[Category: Nameki N]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Ohnishi S]]
[[Category: Tochio, N.]]
[[Category: Tochio N]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Dna binding protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:01:34 2008''
Retrieved from "https://proteopedia.org/2e1o"