1wdz: Difference between revisions

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{{Seed}}
[[Image:1wdz.png|left|200px]]


<!--
==Crystal structure of RCB domain of IRSp53==
The line below this paragraph, containing "STRUCTURE_1wdz", creates the "Structure Box" on the page.
<StructureSection load='1wdz' size='340' side='right'caption='[[1wdz]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wdz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WDZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wdz OCA], [https://pdbe.org/1wdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wdz RCSB], [https://www.ebi.ac.uk/pdbsum/1wdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wdz ProSAT], [https://www.topsan.org/Proteins/RSGI/1wdz TOPSAN]</span></td></tr>
{{STRUCTURE_1wdz|  PDB=1wdz  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of RCB domain of IRSp53===
[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
1WDZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WDZ OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/1wdz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wdz ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Murayama, K.]]
[[Category: Large Structures]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Murayama K]]
[[Category: Seto, A.]]
[[Category: Seto A]]
[[Category: Shirouzu, M.]]
[[Category: Shirouzu M]]
[[Category: Suetsugu, S.]]
[[Category: Suetsugu S]]
[[Category: Takenawa, T.]]
[[Category: Takenawa T]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Cellular signaling protein]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:44:37 2008''
Retrieved from "https://proteopedia.org/1wdz"