1ua5: Difference between revisions
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New page: left|200px<br /><applet load="1ua5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ua5, resolution 2.50Å" /> '''Non-fusion GST from ... |
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== | ==Non-fusion GST from S. japonicum in complex with glutathione== | ||
<StructureSection load='1ua5' size='340' side='right'caption='[[1ua5]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
[[Category: | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ua5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UA5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ua5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ua5 OCA], [https://pdbe.org/1ua5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ua5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ua5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ua5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1ua5_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ua5 ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been studied in the context of drug design. We have determined the crystal structure of non-fused SjGST complexed with glutathione, and compare it to complexes between glutathione and SjGST fusion proteins. | |||
Crystal structure of non-fused glutathione S-transferase from Schistosoma japonicum in complex with glutathione.,Kursula I, Heape AM, Kursula P Protein Pept Lett. 2005 Oct;12(7):709-12. doi: 10.2174/0929866054696154. PMID:16522189<ref>PMID:16522189</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1ua5" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schistosoma japonicum]] | [[Category: Schistosoma japonicum]] | ||
[[Category: Heape AM]] | |||
[[Category: Heape | [[Category: Kursula I]] | ||
[[Category: Kursula | [[Category: Kursula P]] | ||
[[Category: Kursula | |||
Latest revision as of 23:49, 27 December 2023
Non-fusion GST from S. japonicum in complex with glutathione
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