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{{Seed}}
[[Image:3d8e.png|left|200px]]


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==Crystal structure of the human Fe65-PTB1 domain (trigonal crystal form)==
The line below this paragraph, containing "STRUCTURE_3d8e", creates the "Structure Box" on the page.
<StructureSection load='3d8e' size='340' side='right'caption='[[3d8e]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3d8e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D8E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8e OCA], [https://pdbe.org/3d8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d8e RCSB], [https://www.ebi.ac.uk/pdbsum/3d8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d8e ProSAT]</span></td></tr>
{{STRUCTURE_3d8e|  PDB=3d8e  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of the human Fe65-PTB1 domain (trigonal crystal form)===
[https://www.uniprot.org/uniprot/APBB1_HUMAN APBB1_HUMAN] Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).<ref>PMID:15031292</ref> <ref>PMID:18468999</ref> <ref>PMID:18922798</ref> <ref>PMID:19234442</ref> <ref>PMID:19343227</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/3d8e_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18550529}}
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d8e ConSurf].
3D8E is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8E OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Crystal structure of the human Fe65-PTB1 domain., Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K, J Biol Chem. 2008 Aug 22;283(34):23113-20. Epub 2008 Jun 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18550529 18550529]
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</StructureSection>
Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain., Radzimanowski J, Ravaud S, Beyreuther K, Sinning I, Wild K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):382-5. Epub 2008 Apr 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18453707 18453707]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Radzimanowski, J.]]
[[Category: Large Structures]]
[[Category: Ravaud, S.]]
[[Category: Radzimanowski J]]
[[Category: Sinning, I.]]
[[Category: Ravaud S]]
[[Category: Wild, K.]]
[[Category: Sinning I]]
[[Category: Alpha-beta structure]]
[[Category: Wild K]]
[[Category: Phosphotyrosine binding domain]]
[[Category: Protein binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 19 19:25:08 2008''

Latest revision as of 08:23, 20 March 2024

Crystal structure of the human Fe65-PTB1 domain (trigonal crystal form)

3d8e, resolution 2.80Å

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