3cov: Difference between revisions

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{{Seed}}
[[Image:3cov.png|left|200px]]


<!--
==Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form==
The line below this paragraph, containing "STRUCTURE_3cov", creates the "Structure Box" on the page.
<StructureSection load='3cov' size='340' side='right'caption='[[3cov]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3cov]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3cov|  PDB=3cov |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cov OCA], [https://pdbe.org/3cov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cov RCSB], [https://www.ebi.ac.uk/pdbsum/3cov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cov ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3cov_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cov ConSurf].
<div style="clear:both"></div>


===Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form===
==See Also==
 
*[[Pantothenate synthetase|Pantothenate synthetase]]
 
== References ==
==About this Structure==
<references/>
3COV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COV OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Large Structures]]
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate., Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C, Chembiochem. 2008 Nov 3;9(16):2606-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18821554 18821554]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Abell C]]
[[Category: Single protein]]
[[Category: Blundell TL]]
[[Category: Abell, C.]]
[[Category: Chirgadze DY]]
[[Category: Blundell, T L.]]
[[Category: Ciulli A]]
[[Category: Chirgadze, D Y.]]
[[Category: Ciulli, A.]]
[[Category: Atp-binding]]
[[Category: Cytoplasm]]
[[Category: Drug design]]
[[Category: Enzyme]]
[[Category: Ligase]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Nucleotide-binding]]
[[Category: Pantothenate biosynthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 19 20:45:47 2008''
Retrieved from "https://proteopedia.org/3cov"