3bk0: Difference between revisions

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{{Seed}}
[[Image:3bk0.jpg|left|200px]]


<!--
==Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP==
The line below this paragraph, containing "STRUCTURE_3bk0", creates the "Structure Box" on the page.
<StructureSection load='3bk0' size='340' side='right'caption='[[3bk0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bk0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BK0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNU:5-CYANO-URIDINE-5-MONOPHOSPHATE'>CNU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3bk0| PDB=3bk0 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk0 OCA], [https://pdbe.org/3bk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bk0 RCSB], [https://www.ebi.ac.uk/pdbsum/3bk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk0 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
== Function ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/3bk0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bk0 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP===
==See Also==
 
*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
 
== References ==
==Disease==
<references/>
Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
__TOC__
 
</StructureSection>
==About this Structure==
3BK0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK0 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Large Structures]]
[[Category: Avina, M E.M.]]
[[Category: Avina MEM]]
[[Category: Kotra, L P.]]
[[Category: Kotra LP]]
[[Category: Liu, Y.]]
[[Category: Liu Y]]
[[Category: Pai, E F.]]
[[Category: Pai EF]]
[[Category: Tang, H L.]]
[[Category: Tang HL]]
[[Category: 5-cn-ump]]
[[Category: Alternative splicing]]
[[Category: C-terminal domain]]
[[Category: Disease mutation]]
[[Category: Glycosyltransferase]]
[[Category: Human]]
[[Category: Lyase]]
[[Category: Multifunctional enzyme]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
[[Category: Polymorphism]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Transferase]]
[[Category: Ump synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:40:28 2008''
Retrieved from "https://proteopedia.org/3bk0"