3f5c: Difference between revisions

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New page: '''Unreleased structure''' The entry 3f5c is ON HOLD until sometime in the future Authors: Fletterick, R.J., Sablin, E.P. Description: Structure of Dax-1:LRH-1 complex ''Page seeded b...
 
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'''Unreleased structure'''


The entry 3f5c is ON HOLD  until sometime in the future
==Structure of Dax-1:LRH-1 complex==
<StructureSection load='3f5c' size='340' side='right'caption='[[3f5c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [https://pdbe.org/3f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [https://www.ebi.ac.uk/pdbsum/3f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR5A2_MOUSE NR5A2_MOUSE] Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor.


Authors: Fletterick, R.J., Sablin, E.P.
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.,Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:19015525<ref>PMID:19015525</ref>


Description: Structure of Dax-1:LRH-1 complex
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3f5c" style="background-color:#fffaf0;"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:41:47 2008''
==See Also==
*[[Liver receptor homolog-1|Liver receptor homolog-1]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Fletterick RJ]]
[[Category: Sablin EP]]
Retrieved from "https://proteopedia.org/3f5c"