1uhs: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /><applet load="1uhs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uhs" /> '''Solution structure of mouse homeodomain-only... |
No edit summary |
||
| (14 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==Solution structure of mouse homeodomain-only protein HOP== | ||
<StructureSection load='1uhs' size='340' side='right'caption='[[1uhs]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1uhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [https://pdbe.org/1uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB], [https://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhs ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhs TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhs_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhs ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[HOP protein|HOP protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Aoki M]] | |||
[[Category: Aoki | [[Category: Arakawa T]] | ||
[[Category: Arakawa | [[Category: Carninci P]] | ||
[[Category: Carninci | [[Category: Hayashizaki Y]] | ||
[[Category: Hayashizaki | [[Category: Hirota H]] | ||
[[Category: Hirota | [[Category: Inoue M]] | ||
[[Category: Inoue | [[Category: Kawai J]] | ||
[[Category: Kawai | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Matsuda T]] | ||
[[Category: Matsuda | [[Category: Osanai T]] | ||
[[Category: Osanai | [[Category: Saito K]] | ||
[[Category: Seki E]] | |||
[[Category: Saito | [[Category: Shirouzu M]] | ||
[[Category: Seki | [[Category: Tanaka A]] | ||
[[Category: Shirouzu | [[Category: Terada T]] | ||
[[Category: Tanaka | [[Category: Yabuki T]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Yabuki | [[Category: Yoshida M]] | ||
[[Category: Yokoyama | |||
[[Category: Yoshida | |||
Latest revision as of 23:53, 27 December 2023
Solution structure of mouse homeodomain-only protein HOP
| ||||||||||||
