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New page: left|200px<br /><applet load="1uos" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uos, resolution 2.7Å" /> '''THE CRYSTAL STRUCTURE...
 
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[[Image:1uos.gif|left|200px]]<br /><applet load="1uos" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1uos, resolution 2.7&Aring;" />
'''THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN'''<br />


==Overview==
==The Crystal Structure of the Snake Venom Toxin Convulxin==
Snake venoms contain a number of proteins that interact with components of, the haemostatic system that promote or inhibit events leading to, blood-clot formation. The snake-venom protein convulxin (Cvx) binds, glycoprotein (GP) VI, the platelet receptor for collagen, and triggers, signal transduction. Here, the 2.7 A resolution crystal structure of Cvx, is presented. In common with other members of this snake-venom protein, family, Cvx is an alphabeta-heterodimer and conforms to the C-type, lectin-fold topology. Comparison with other family members allows a set of, Cvx residues that form a concave surface to be putatively implicated in, GPVI binding. Unlike other family members, with the exception of, flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric, structure is consistent with Cvx clustering GPVI molecules on the surface, of platelets and as a result promoting signal transduction activity. The, Cvx structure and the location of the putative binding sites suggest a, model for this multimeric signalling assembly.
<StructureSection load='1uos' size='340' side='right'caption='[[1uos]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1uos]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UOS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uos OCA], [https://pdbe.org/1uos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uos RCSB], [https://www.ebi.ac.uk/pdbsum/1uos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uos ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLA_CRODU SLA_CRODU] Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113).<ref>PMID:9153205</ref> <ref>PMID:16102113</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uo/1uos_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uos ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation. The snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI, the platelet receptor for collagen, and triggers signal transduction. Here, the 2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms to the C-type lectin-fold topology. Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding. Unlike other family members, with the exception of flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure is consistent with Cvx clustering GPVI molecules on the surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly.


==About this Structure==
Structure of the snake-venom toxin convulxin.,Batuwangala T, Leduc M, Gibbins JM, Bon C, Jones EY Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):46-53. Epub 2003, Dec 18. PMID:14684891<ref>PMID:14684891</ref>
1UOS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UOS OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of the snake-venom toxin convulxin., Batuwangala T, Leduc M, Gibbins JM, Bon C, Jones EY, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):46-53. Epub 2003, Dec 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14684891 14684891]
</div>
<div class="pdbe-citations 1uos" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Crotalus durissus terrificus]]
[[Category: Crotalus durissus terrificus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Batuwangala, T.]]
[[Category: Batuwangala T]]
[[Category: Bon, C.]]
[[Category: Bon C]]
[[Category: Gibbins, J.M.]]
[[Category: Gibbins JM]]
[[Category: Jones, E.Y.]]
[[Category: Jones EY]]
[[Category: Leduc, M.]]
[[Category: Leduc M]]
[[Category: SPINE, Structural.Proteomics.in.Europe.]]
[[Category: c-type lectin]]
[[Category: convulxin]]
[[Category: gpvi]]
[[Category: snake toxin]]
[[Category: spine]]
[[Category: structural genomics]]
[[Category: structural proteomics in europe]]
 
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Latest revision as of 00:34, 21 November 2024

The Crystal Structure of the Snake Venom Toxin Convulxin

1uos, resolution 2.70Å

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